| 16.01.2021 16:00 | Arsenal | : | Newcastle United | |
| 16.01.2021 16:00 | Aston Villa | : | Everton | |
| 16.01.2021 16:00 | Fulham | : | Chelsea | |
| 16.01.2021 16:00 | Leeds United | 0 : 1 | Brighton | |
| 16.01.2021 16:00 | Leicester City | : | Southampton | |
| 16.01.2021 16:00 | Liverpool | : | Manchester United | |
| 16.01.2021 16:00 | Manchester City | : | Crystal Palace | |
| 16.01.2021 16:00 | Sheffield United | : | Tottenham Hotspur | |
| 16.01.2021 16:00 | West Ham United | 1 : 0 | Burnley | |
| 16.01.2021 16:00 | Wolverhampton | 2 : 3 | West Bromwich Albion |
| 16.01.2021 15:30 | Borussia Dortmund | 1 : 1 | Mainz 05 | |
| 16.01.2021 15:30 | Hoffenheim | 0 : 0 | Arminia | |
| 16.01.2021 15:30 | Wolfsburg | 2 : 2 | RB Leipzig | |
| 16.01.2021 15:30 | Köln | 0 : 0 | Hertha BSC | |
| 16.01.2021 15:30 | Werder | 2 : 0 | Augsburg | |
| 2.pol 2.pol. | Stuttgart | 0 : 1 | Borussia M'gladbach |
| 16.01.2021 21:00 | Angers SCO | : | PSG | |
| 16.01.2021 17:00 | Olympique Marseille | 1 : 2 | Nîmes |
| 16.01.2021 15:00 | Bologna | 1 : 0 | Hellas Verona | |
| 16.01.2021 20:45 | Sampdoria | : | Udinese | |
| 2.pol 2.pol. | Torino | 0 : 0 | Spezia |
| 16.01.2021 19:00 | Bosna Kompred | : | Kaskada | |
| 16.01.2021 16:30 | Policajac | 5 : 0 | Zrinjski | |
| 16.01.2021 18:00 | Sloga | : | Seljak |
| 16.01.2021 20:00 | Cibona | : | Mornar | |
| 4/4 | Budućnost VOLI | 73 : 65 | Partizan NIS |
| 16.01.2021 20:00 | Čapljina | 88 : 87 | Bosna Royal | |
| 16.01.2021 20:00 | Mladost | 83 : 87 | Bratunac | |
| 16.01.2021 20:00 | Promo | 84 : 83 | Zrinjski | |
| 16.01.2021 20:00 | Široki | 101 : 78 | Leotar |
| 16.01.2021 | Mladost Buldogs | : | Rogatica | |
| 16.01.2021 | HEO | : | Student Igokea | |
| 16.01.2021 | Drina Princip | : | Prijedor Spartak | |
| 16.01.2021 | Sutjeska | : | Radnik BN Basket | |
| 16.01.2021 | Slavija | : | Sokolac |
| 16.01.2021 20:00 | Podgorica | 64 : 83 | Studentski centar | |
| 16.01.2021 20:00 | Sutjeska | 83 : 77 | Jedinstvo 1950 |
| 16.01.2021 17:00 | Cinkarna Celje | 49 : 68 | Budućnost Bemax |
| 16.01.2021 18:00 | Igman | 62 : 87 | Play Off Ultra | |
| 16.01.2021 18:00 | Orlovi | : | Leotar 03 | |
| 16.01.2021 18:00 | Čelik | : | Mladi Krajišnik | |
| 16.01.2021 18:00 | Brčanka | : | Džamper | |
| 16.01.2021 18:00 | Rudar Sport | : | Jedinstvo Dženeks | |
| 16.01.2021 18:00 | Feniks | 89 : 53 | Konjic |
| 16.01.2021 11:30 | Lavovi | 94 : 35 | Mladost Basket Una |
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